Selected Publications

Prentzell, M.T.*, Rehbein, U.*, Sandoval, M.C.*, De Meulemeester, A.S.*, (…) Opitz, C.A.#, Thedieck, K.# (2021). The G3BP proteins tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell; 184:655-674.e27. Open access,doi: 10.1016/j.cell.2020.12.024. (*equally contributing first authors, # shared corresponding and last authors)

Sadik A.*, Somarribas Patterson L.F.*, Öztürk S*., Mohapatra S.R.*, (…), Trump S.*, Seiffert M.*, Opitz C.A.*#. (2020). IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. Aug 17:S0092-8674(20)30946-6. Open access, doi: 10.1016/j.cell.2020.07.038. (*co-first or co-last authors, #corresponding author)

Panitz V, Končarević S, Sadik A, (…), Opitz CA. (2021) Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma. Theranostics. 3;11(19):9217-9233. Open access, doi: 10.7150/thno.60679.

Mohapatra S.R., (…), Opitz C.A. (2021) Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production. Front Immunol 12(8). Feb 19;12:590532. Open access, doi: 10.3389/fimmu.2021.590532

Mohapatra S.R., (…), Opitz C.A. (2019) Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma. Front Immunol. Dec 4;10:2762. Open access, doi 10.3389/fimmu.2019.02762. 

Adam I., Dewi D.L., (…), Opitz C.A. (2018) Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. Oncoimmunology. Sep 5;

(12):e486353. Open access, doi: 10.1080/2162402X.2018.1486353. (*co-first authors)7. Dewi, D.L., (…), Opitz, C.A., (2017) Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology. 2017;6(2):e1274477. Open access, doi: 10.1080/2162402X.2016.1274477.

Opitz C.A., (…), Trump S. (2020) The therapeutic potential of targeting tryptophan catabolism in cancer. Br J Cancer. Jan;122(1):30-44. Open access, doi: 10.1038/s41416-019-0664-6.

Platten M.,(…), Opitz C.A. (2019) Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. May;18(5):379-401. doi: 10.1038/s41573-019-0016-5.

Opitz CA*, Litzenburger UM*, (…), Platten M. (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. Oct 5;478 (7368):197-203. doi: 10.1038/nature10491. (*shared first authorship)