Übersicht

Dr. Hind Medyouf studied biology and biochemistry at the university Paris VII, France. As a PhD at the Institute Curie in France, she identified the pro-oncogenic effects of the calcineurin/NFAT signaling in the pathogenesis of T-cell acute lymphoblastic leukemia. Dr. Medyouf subsequently trained as an HFSP postdoctoral fellow at the Terry Fox Laboratory where she continued working on deregulated signaling pathways in T-ALL (Vancouver, Canada) before joining the team of Andreas Trumpp as an EMBO postdoctoral fellow at the German Cancer Research Centre (DKFZ, Heidelberg, Germany). In the Trumpp's lab, Dr. Medyouf focused on exploring the fundamental biological properties of hematopoietic stem cells and used this knowledge to gain novel insight on the mechanisms underlying the pathogenesis of myelodysplastic syndromes (MDS), with a particular emphasis on the role of the bone marrow microenvironment. Since 2014, Dr. Medyouf is a DKTK faculty member, leading an ERC supported research group at the Institute for Tumor Biology and Experimental Therapy and the Frankfurt Cancer Institute (Frankfurt, Germany). Her current research is focused on exploring the role of the tumor microenvironment in leukemia and solid cancer metastasis. In particular, the group is investigating the complex cellular interactions and molecular mechanisms by which tumor cells co-opt their surrounding stroma to promote immune escape and therapeutic resistance.