Selected Publications
Chan TEH, Islam MS, Fotouhi O, Bozkurt M, Sheikh N, Schüle KM, Arnold SJ, Timmers HTM (2026). MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling. Genes Dev 40, 13-14:1012-1028.
PMID: 42031562 DOI: 10.1101/gad.353313.125
Capponi S, Ehret S, Camgöz Z, Gather F, Vaine CA, Özyerli-Göknar E, Follo M, Bragg C, Vogel T, Timmers HTM (2026). Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. Nat Commun 17, 4062.
PMID: 42086561 PMCID: PMC13144358 DOI: 10.1038/s41467-026-72319-6
Fetsch V, Schwöbel L, Ozyerli-Goknar E, Stell AV, Punta M, Plenge T, Klaus T, Gupta MK, Andrieux G, Shoumariyeh K, Pfeiffer S, Corrales E, Schlenke L, Baniadam H, Brandl SM, Andreis M, Remen M, Hartmann A, Grueter K, Zwick M, Köhler N, Kuban M, Metzger E, Rummelt C, Duyster J, Boerries M, Hofmann M, Färber J, Braun LM, Zähringer A, Lübbert M, Toffalori C, Vago L, Heidel FH, Minguet S, Apostolova P, Feuchtinger T, Maas-Bauer K, Blaeschke F, Kühn MWM, Timmers HTM, Wertheimer T, Perner F, Zeiser R (2026). Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML. Blood 147, 584-601
PMID: 41144759 DOI: 10.1182/blood.2025029712
Pulido-Cortés L, Gielingh H, Thijssen V, Liu M, Yoshisada R, Romão Soares L, Sheikh N, Friedrich F, Greschik H, Peng L, Vargas Honorato R, Jung M, Bonvin AMJJ, Biniossek ML, Schüle R, Jongkees S, van Ingen H, Timmers HTM (2025). Molecular determinants for recognition of serotonylated chromatin. Nucleic Acids Res 53:gkaf612.
PMID: 40637225 PMCID: PMC12238850 DOI: 10.1093/nar/gkaf612
Sheikh N, Timmers HTM (2024). greenPipes: an integrated data analysis pipeline for greenCUT&RUN and CUT&RUN genome-localization datasets. Bioinformatics 40:btae307
PMID: 38718209 PMCID: PMC11112040 DOI: 10.1093/bioinformatics/btae307
Sheikh N, Koidl S, Bhuiyan T, Werner TV, Biniossek ML, Bonvin AMJJ, Lassmann S, Timmers HTM (2021). Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN. Nucleic Acids Res 49:e49.
PMID: 33524153 PMCID: PMC8136828 DOI: 10.1093/nar/gkab038
Koster MJ, Timmers HTM (2015). Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes. Nucleic Acids Res 43, 143-152.
PMID: 25432956 PMCID: PMC4288163 DOI: 10.1093/nar/gku1263
Dreijerink KMA, Conemans EB, Cornelissen C, van Blokland MT, Mannstadt M, Pieterman CR, Binquet C, Dekkers OM, Drent ML, Horst-Schrivers AN, et al (2014). Breast-cancer predisposition in multiple endocrine neoplasia type 1. N Engl J Med 371, 583-584.
PMID: 25099597 PMCID: PMC4243053 DOI: 10.1056/NEJMc1406028
Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch H, Moritz S, et al (2013). A central role for TFIID in the pluripotent transcription circuitry. Nature 495, 516-519.
PMID: 23503660 DOI: 10.1038/nature11970
Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HTM (2007). Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell 131, 58-69.
PMID: 17884155 DOI: 10.1016/j.cell.2007.08.016