Selected Publications

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation. Mühlgrabner V, Peters T., Velasco Cárdenas R.M.H., Salzer B., Göhring J., Plach A,, Höhrhan M., Doel Perez I., Dos Reis Gonçalves V., Siller-Farfán J., Lehner M., Stockinger H., Schamel W.W., Schober K., Busch D.H., Hudecek M., Dushek O., Minguet S., Platzer R, Huppa J.B.* (2024) Science Advances 10(36):eadj4632. doi: 10.1126/sciadv.adj4https://pubmed.ncbi.nlm.nih.gov/30013143/632

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion. Platzer R., Hellmeier J., Göhring J., Doel-Perez I., Schatzlmaier P., Bodner C., Schütz G.J., Sevcsik E., Stockinger H., Brameshuber H., Huppa J.B.* (2023) EMBO Reports Sep 28:e57842. doi: 10.15252/embr.202357842 

Temporal Analysis of T-Cell Receptor-Imposed Forces via Quantitative Single Molecule FRET Measurements. Göhring J., Kellner F., Schrangl L., Platzer R., Klotzsch E., Stockinger H., Huppa J.B.*, Schütz G.J. (2021) Nature Communications  4;12(1):2502. doi: 10.1038/s41467-021-22775-z. PMID: 33947864.

Inefficient CAR-proximal signaling blunts antigen detection. Gudipati V., Rydzek J. Doel Perez I., Scharf L., Königsberger S., Lobner E., Dos Reis Gonçalves V., Kunert R., Einsele H., Stockinger H., Hudecek M. and Huppa J.B.* (2020) Nature Immunology 21:848-856 doi: 10.1038/s41590-020-0719-0. online ahead of print. PMID: 32632291

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells. Rossboth B., Arnold A.M., Ta H., Platzer R., Kellner F., Huppa J.B., Brameshuber M., Baumgart F., Schütz G.J. (2018) Nature Immunology 19(8):821-827, doi: 10.1038/s41590-018-0162-7