Selected publications

Lu I, Heming M, Cheung PF, Thomas C, Giglio G, Erdemir M, Wirth T, König S, Dambietz C, Schroeter C, Nelke C, Siveke JT, Ruck T, Klotz L, Leo M, Kleinschnitz C, Wiendl H, Hagenacker T. Cell-mediated cytotoxicity surrounding the brain in spinal muscular atrophy. Submitted to Nat Comm. Accepted. 

Hamacher R, Pabst KM, Cheung PF, Heilig CE, Hüllein J, Liffers ST, Borchert S, Costa PF, Schaarschmidt BM, Kessler L, Miera MA, Droste M, Akbulut M, Falkenhorst J, Zarrad F, Kostbade K, Mavroeidi IA, Glimm H, Umutlu L, Schuler M, Hübschmann D, Bauer S, Fröhling S, Herrmann K, Siveke JT, Schildhaus HU, Fendler WP. Fibroblast Activation Protein α-Directed Imaging and Therapy of Solitary Fibrous Tumor. J Nucl Med. 2024 Feb 1;65(2):252-257. Doi: 10.2967/jnumed.123.266411.

Cameron DP, Grosser J, Ladigan S, Kuzin V, Iliopoulou E, Wiegard A, Benredjem H, Jackson K, Liffers ST, Lueong S, Cheung PF, Vangala D, Pohl M, Viebahn R, Teschendorf C, Wolters H, Usta S, Geng K, Kutter C, Arsenian-Henriksson M, Siveke JT, Tannapfel A, Schmiegel W, Hahn SA, Baranello L. Co-inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription. Sci Adv. 2023. Oct 13;9(41):eadg5109. 

Pabst KM, Trajkovic-Arsic M, Cheung PFY, Ballke S, Steiger K, Bartel T, Schaarschmidt BM, Milosevic A, Seifert R, Nader M, Kessler L, Siveke JT, Lueckerath K, Kasper S, Herrmann K, Hirmas N, Schmidt HH, Hamacher R, Fendler WP. Superior Tumor Detection for 68Ga-FAPI-46 Versus 18F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma. J Nucl Med. 2023 Jul;64(7):1049-1055. 

Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP. Fibroblast activation protein inhibitor theranostics: The case for use in Sarcoma. PET Clin. 2023 Jul;18(3):361-367.
 
Cheung PF, Yang J, Fang R, Borgers A, Krengel K, Stoffel A, Althoff K, Yip CW, Siu EH, Ng LW, Lang KS, Cham L, Engel DR, Soun C, Cima I, Scheffler B, Striefler JK, Sinn M, Bahra M, Pelzer U, Oettle H, Markus P, Smeets EMM, Aarntzen EHJG, Savvatakis K, Liffers S, Lueong SS, Neander C, Bazarna A, Zhang X, Paschen A, Crawford HC, Chan AWH, Cheung ST, Siveke JT. Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression. Nat Commun. 2022. Jan 10;13(1):156. 

Rosery V, Reis H, Savvatakis K, Kowall B, Stuschke M, Paul A, Dechêne A, Yang J, Zhao B, Borgers A, Kasper S, Schuler M, *Cheung PF, Siveke JT. Antitumor immune response is associated with favorable survival in GEP-NEN G3. Endocr Relat Cancer. 2021. Sep 2;28(10):683-693. *co-correspondence. 

Zhang X, Zegar T, Weiser T, Hamdan FH, Berger BT, Lucas R, Balourdas DI, Ladigan S, Cheung PF, Liffers ST, Trajkovic-Arsic M, Scheffler B, Joerger AC, Hahn SA, Johnsen SA, Knapp S, Siveke JT. Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int J Cancer. 2020 Nov 15; 147(10):2847-2861. 

Fung SW, Cheung PF, Yip CW, Ng LW, Cheung TT, Chong CC, Lee C, Lai PB, Chan AW, Tsao GS, Wong CH, Chan SL, Lo KW, Cheung ST. The ATP-binding Cassette Transporter ABCF1 is a hepatic oncofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma. Cancer Lett. 2019. Aug 10;457:98-109.

Cheung PF, Neff F, Neander C, Bazarna A, Savvatakis K, Liffers ST, Althoff K, Lee CL, Moding EJ, Kirsch DG, Saur D, Bazhin AV, Trajkovic-Arsic M, Heikenwalder MF, Siveke JT. Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting. Cancer Research. 2018 Sep 1;78(17):4997-5010. 

Cheung PF, Lutz M, Siveke JT. Immunotherapy and combination strategies in pancreatic cancer: current status and emerging trends. Oncol Res Treat. Review. 2018 Apr 41(5):286-290.

Cheung PF, Yip CW, Ng LW, Wong CK, Cheung TT, Lo CM, Fan ST, Cheung ST. Restoration of natural killer activity in hepatocellular carcinoma patients by treatment with antibody against granulin-epithelin precursor. OncoImmunology. 2015 Apr 1;4(7):e1016706. 

Cheung PF, Yip CW, Wong NC, Fong DY, Ng LW, Wan AM, Wong CK, Cheung TT, Ng IO, Poon RT, Fan ST, Cheung ST. Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity. Cancer Immunol Res. 2014 Dec;2(12):1209-19. (IF 6,665)

Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST. GEP and ABCB5 regulate liver cancer chemoresistance. Gastroenterology. 2011 Jan;140(1):344-55. 

Cheung PF, Wong CK, Lam CW. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17F and IL-23: implications for Th17 lymphocyte-mediated allergic inflammation. J Immunol. 2008; 180(8): 5625-5635. 

Cheung PF, Wong CK, Ip WK, Lam CW. FAK-mediated activation of ERK for eosinophil migration: a link between infection and allergic inflammation. Int Immunol. 2008; 20(3):353-363. 

Wong CK, Cheung PF, Lam CW. Leptin-induced cytokine release and migration of eosinophil: implication for immunopathophysiology of allergic inflammation. Eur J Immunol. 2007; 37(8):2337-2348. 

Wong CK, Cheung PF, Ip WK, Lam CW. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007; 37(1):85-96. 

Cheung PF, Wong CK, Ip WK, Lam CW. IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation. Allergy.   2006; 61(7):878-885.

Wong CK, Cheung PF, Ip WK, Lam CW. Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB. Am J Respir Cell Mol Biol. 2005;33(2):186-194.

Book chapters

Chapter: “Methods to analyze the role of progranulin on cancer stem cell features”; In “Progranulin”, by Springer. 
Cheung PF, Cheung ST. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features. Methods Mol Biol. 2018;1806:145-153.