From 26/01/2023 To 26/01/2023

Starts at 16:00 until 17:00

18 th Web seminar ‘Epigenetics and Metabolism’: Obesity induced long-term remodelling of the adipocyte epigenome

  • Address: Virtual
  • Language: English
  • Registration necessary: No

Dear All,

It is with great pleasure that we announce Prof. Ferdinand von Meyenn, Assistant Professor at the ETH Zurich, Switzerland, who will give a virtual talk on January 26th at 16:00 CET titled “Obesity induced long-term remodelling of the adipocyte epigenome”. The following are the specifics of his presentation:     

Speaker: Prof. Ferdinand von Meyenn, ETH Zurich, Switzerland

Talk: Obesity induced long-term remodelling of the adipocyte epigenome

Location: On Zoom (Meeting ID: 848 3517 6193; Passcode: 69610258). Free registration Link: https://us02web.zoom.us/webinar/register/WN_MFPkxXFPR-6-fW_4deiOQA       

Abstract: Chronic nutritional challenges can alter the function and capacity of adipose tissue (AT) to adapt to new challenges, contributing to AT dysfunction and pathophysiological conditions which can persist long-term. We study how high fat diet (HFD), can elicit a long-term nutritional memory, including cellular, molecular, and epigenetic changes in the epididymal AT (epiAT), and how this is maintained even after weight loss. We fed mice a HFD for 12 or 24 weeks and then switched them back to a chow diet (CD) for 8 weeks. Body weight and glucose homeostasis did rapidly normalize in the 12 week HFD challenged cohort, but single nuclei sequencing (snRNAseq), physiological phenotyping, and epigenetic characterization of the epiAT showed that several features of high fat diet feeding did nor reverse. We found that an expansion of macrophage and progenitor cells (APCs), a strong decrease in the proportion of adipocytes, and the appearance of new APCs clusters upon HFD. The cellular obese phenotypes were largely resolved by weight loss in the 12 week HFD, while 24 week HFD result in permanent epiAT remodeling. Molecular analysis indicate that these changes are also imprinted in the epigenome of the adipocytes and cannot be reversed completely. We expect that human obesity closer resembles our long-term HFD and understanding the cellular and molecular mechanisms of epiAT plasticity will help to mitigate obesity-related diseases and increase the efficacy of the treatments.

Biography: Ferdinand von Meyenn has been Assitiant Professor of the Institute of Food Nutrition and Health at the ETH Zurich since January 2019.
Ferdinand studied Biochemistry at the TU Müchnen, Germany, before moving to ETH Zürich for his PhD to study metabolism and type-2 diabetes. After his graduation, he joined Prof Wolf Reik at the Babraham Institute in Cambridge, UK, and investigated epigenetic mechanisms during development and ageing. In 2017 he joined King’s College London as a Research Fellow and then moved in 2019 to ETH Zurich where he was appointed Assistant Professor for Nutrition and Metabolic Epigenetics. His research focuses on the complex relationship between nutrition, metabolism and the epigenome, with the aim to contribute to the development of novel strategies to combat obesity and metabolic disease.