Summary

Our research focuses on Systems Immune Oncology, with particular emphasis on single-cell and spatial multi-omics technologies to study tumor and immune cell states. We combine experimental and computational strategies to map cellular programs and interactions that drive therapy resistance and (immuno-)therapy response. By integrating transcriptomic, epigenomic, and immune receptor profiling at single-cell resolution, we aim to uncover the molecular rules of cell state transitions and to identify predictive biomarkers and therapeutic targets. Ultimately, our goal is to translate these insights into more effective and durable immunotherapies for patients with cancer.

Labor Frede - Systems Immune Oncology