DKTK Core Facilities: Imaging
© BERIC Charité, Berlin
Berlin Experimental Radionuclide Imaging Center (BERIC)
The BERIC offers as a core facility of the Charité all modalities of modern hybrid small animal imaging with radiopharmaceuticals.
The multidisciplinary team is using its expertise and the latest state-of-the-art equipment (SPECT / CT, PET / MR; Angiography/PET, Fig. 2) available to users. The service offered includes all steps from consulting to study design, the tracer selection, tracer production, keeping of radioactive animals, conduction of the animal experiments, including image and data analysis and data storage as well as post mortem biodistribution experiments. The BERIC also offers services such as radiolabeling of ligands, in vitro evaluation of tracers and the generation of (genetically modified) cell lines and animal models (orthotopic, subcutaneous and metastatic tumor, stroke and myocarditis models etc.). Own research interests within the BERIC concentrate on the development and characterization of new radiotracers and theranostics for various tumor entities, as well as the development of new quantitative multi-parametric imaging approaches.
Small Animal Imaging and Radiotherapy Platform
Preclinical in vivo studies using small animals are essential to develop new therapeutic options in radiation oncology. Of particular interest for radiation oncology are tumor xenografts and orthotopic tumor models, which better reflect the clinical situation in terms of growth patterns and micro-environmental parameters of the tumor as well as the interplay of tumors with the surrounding normal tissue. Orthotopic models increase the technical demands and the complexity of preclinical studies as local irradiation with therapeutically relevant doses requires image-guided target localization and accurate beam application. Furthermore, advanced imaging techniques are needed for monitoring treatment outcome. Dresden features the full spectrum of bio-imaging, radiomics and image-guided radiotherapy (IGRT) for small animals. Available bio-imaging facilities include CT, PET/CT, PET/MRI, ultrasound and optical imaging (e.g. bioluminisence). Next to a fully equipped conventional small X-ray animal irradiation platform, a novel small animal image-guided radiation therapy (SAIGRT) system was developed in Dresden. It allows precise and accurate, conformal radiation therapy and x-ray imaging of small animals.
IMCES - Imaging Center Essen
IMCES is a core facility within the Institut für Experimentelle Immunologie und Bildgebung at the Faculty of Medicine, Universitätsklinikum Essen and Universität Duisburg-Essen. The facility brings together state-of-the-art equipment and expertise in light and electron microscopy, in vivo and intravital imaging, and image analysis. These services are available to all researchers, irrespective of location and affiliation.
The IMCES laboratories and microscopy rooms have permission for working at the S1 and S2 biological safety level.
Cell Sorting and Imaging Facility Freiburg
The CCCF member department Hematology, Oncology and Stem Cell Transplantation operates a core facility for FACS based cell analysis, high speed cell sorting, confocal microscopy and high content screening/image cytometry.