From 04.12.2019 to 04.12.2019

Starts at 18:00 until 20:00

Perspective Lectures in Oncology: Targeting the tumour stroma to limit breast cancer metastasis

Venue: Universitätsklinikum Frankfurt, Haus 2, Hörsaal 22-1
Speaker: Clare Isacke
Organizer: Ivan Dikic, IBC II
Language: English
Registration necessary: no

The Molecular Cell Biology Team seeks to identify strategies to effectively target key tumour-environment crosstalk pathways to limit metastatic relapse and enhance the efficacy of tumour targeting agents. Cancer-associated fibroblasts (CAFs) and activated pericytes participate in tumour development not only by their impact on cancer cells via paracrine signalling and the deposition of a neoplastic extracellular matrix, but also by their influence on other stromal populations - particularly in promoting a immunosuppressive, pro-tumour microenvironment. The presentation will address our current research in (a) assessing the efficacy of targeting CAF subpopulations to reduce breast cancer metastatic colonisation, (b) the mechanisms by which CAF-immune cell crosstalk influences tumour growth and response to therapy, and (c) the role of therapy-induced stromal damage in promoting metastatic relapse.


More information can be found on this webpage.


Wir setzen Cookies ein, um unsere Website nutzerfreundlicher zu gestalten. Weitere Informationen erhalten Sie in der Datenschutzerklärung. Zur Datenschutzerklärung.