HIRO and OncoRay Lecture Series: Translational Radiooncology (Prof. Dr. Dr. Amir Abdollahi)

In  this  HIRO  research  focus  high  precision  radiation  oncology  is  integrated  into  curative 
multimodal therapy concepts. In field of precision radiotherapy, the radiobiological impact of 
novel particle therapy qualities i.e. proton, helium, carbon to oxygen ions developed at HIT are 
investigated.  This unique  beam  parameter  space  is  utilized to  identify  strategies  to  eradicate 
resistant  tumor  subpopulations  such  as  hypoxic  and  stem-cell  like  cells  and  to  explore  their 
impact on tumor-immune microenvironment communication. Towards broadening the 
therapeutic window, investigation of normal tissue tolerance to multimodal therapies and their 
effect on inflammatory response, organ dysfunction and ultimately development of fibrosis are 
also of utmost significance. Inevitably, precision therapy requires precision diagnostic to stratify 
or even personalize treatment. With a reverse translation approach, compendium imaging and 
molecular diagnostics are developed to select patients most benefiting from designed 
multimodal therapy strategies within a program. Overall, the mission of this research area is to 
develop  the  next  generation  radiation  oncology  by  integrating  the  rapidly  evolving  field  of 
cellular- and molecular biology into a multidisciplinary adaptive radiotherapy.

You can find all information on the HIRO and OncoRay Lecture Series Website.