M3 Lecture: Metabolism and Immunity Go Viral

Prof. Dr. Samuel Nobs of the Zurich University will visit the M3  Research Center, Tübingen, rooms 2.208/209 and give a lecture.

Abstract:
People with diabetes feature a life-risking susceptibility to lung viral infection, including influenza and SARS-CoV-2, whose mechanism remains unknown. In acquired and genetic mouse models of diabetes with an acute pulmonary viral infection, we demonstrate that hyperglycemia leads to defective antiviral adaptive immunity, delayed viral clearance and enhanced mortality. Mechanistically, hyperglycemia induces an altered metabolic-epigenetic circuitry in dendritic cells which drive impaired key immune functions. Either glucose-lowering treatment or pharmacological modulation of key metabolic or epigenetic checkpoints can rescue dendritic cell function and antiviral immunity. Collectively, we identify a hyperglycemia-driven metabolic-immune axis orchestrating dendritic cell dysfunction during pulmonary viral infection and identify metabolic targets that may be therapeutically exploited to mitigate exacerbated disease in diabetics. 

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Meeting-ID: 679 8792 8634
Meeting code: 547088