Summary

Florian Bassermann is director at the Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie des Klinikums rechts der Isar.
The Research in his lab focuses on the molecular pathophysiology and evolution of malignant diseases, particularly hematological neoplasms, such as B-cell malignancies and acute leukemias, as well as selected solid entities including lung cancer and GI cancer. Functionally, we focus on aberrant ubiquitin-dependent signaling pathways and other posttranslational mechanisms, which play pivotal roles in the regulation of tumorrelevant cellular processes such as cell cycle regulation, DNA damage response, immune responses, cell metabolism and programmed cell death.

Starting from a discovery-driven approach that combines multi-OMIC technologies (tumor genomics and functional proteomics) with cell biology, preclinical mouse models and analyses in large, defined patient cohorts, our central task is to forward our new functional insights to direct translational application. To this end, we define and validate new therapeutic target structures and engage in respective drug development efforts, either in academia or in collaboration with pharmaceutical companies, to develop new treatment strategies that are investigated in early clinical trials.

Further information is provided at https://med3.mri.tum.de/de/cell-biology-cancer.