Researcher Database
Prof. Dr. Frederick Klauschen
Pathologisches Institut der LMU
Thalkirchner Str. 36
80337 München
Program
Exploitation of Oncogenic Mechanisms (EOM)
Summary
Our lab integrates histomorphology, genomics and proteomics techniques with novel computational approaches including image analysis, bioinformatics and machine learning-based modeling to better understand tumor pathology and predict optimal precision therapies for cancer patients. A primary focus is to establish proteomics approaches in the identification of therapeutic targets and mechanisms of resistance to targeted therapy in tumor models and primary patient tissue to complement mutational profiling in cancer diagnostics. Moreover, we apply machine learning approaches to histological images and proteogenomic profiling data to predict molecular properties from histomorphology and infer pathologically relevant molecular mechanisms.
DKTK Junior Group Leader for Cancer Systems Biology
Single-cell approaches have not only revealed a wide variety of cell states, characterized by cells exhibiting striking differences in their transcriptional profile, but have also illuminated the mechanisms underlying state transitions in health and disease. Cellular plasticity and adaptive state changes have recently emerged as a basis for therapeutic resistance in cancer, and a better understanding of how cell state transitions are regulated is critical to develop therapeutic approaches that can overcome therapy resistance.
Our research focuses on understanding the mechanisms driving non-genetic cellular heterogeneity and therapy resistance in malignancy. Using novel single-cell sequencing approaches, we seek to develop new experimental and computational strategies to define altered cell states in both, cancer and immune cells. Our aim is to leverage a data driven strategy combined with single cell genomics and systems biology to address the challenges posed by heterogeneity in cancer, and to develop new strategies to overcome it, with the aim of translating laboratory-based findings into the clinic.