Project overview Joint Funding

iVacALL (Prospective phase I/II study: Patient-individualized peptide vaccination based on whole exome sequencing with adjuvant GM-CSF and IFNa in children with relapsed acute lymphoblastic leukemia)

Program: CI Funding Line: INNOVATION Project type: IIT/clinical study Partner site: Berlin, Essen/Dusseldorf, Heidelberg, Munich, Tubingen Entity: blood cancer Status: completed

JF-PSMA (Combined molecular and imaging-based characterization and prognostication of primary high risk prostate cancer from the multicenter 68Ga-PSMA-11 DKTK trial)

Program: ROI Funding Line: UPGRADE Project type: study-related research project Partner site: Dresden, Essen/Dusseldorf, Freiburg, Heidelberg, Munich Entity: prostate cancer Status: current

JIP (DKTK Joint Imaging Platform)

Programs: Overarching Funding Line: strategic initiative Project type: technology platform Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: current

LeOPARD (Rapid liquid biopsy and intraoperative diagnostics)

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: current

MARRIAGE (Impaired DNA Repair)

Program: MTT Funding Line: UPGRADE Project type: study-related research project Partner site: Dresden, Frankfurt/Mainz, Heidelberg Entity: multiple entities Status: completed

MASTER (Cross-Entity Molecular Stratification Program for Evaluation of Individualized, Biology-Driven Therapy in Younger Adults with Advanced-Stage Cancer and Patients with Rare Tumors)

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: current

MEMORI (Imaging, molecular, and clinical features in GEJ Ca)

Program: MDEB Funding Line: UPGRADE Project type: study-related research project Partner site: Essen/Dusseldorf, Heidelberg, Munich Entity: oesophageal cancer Status: completed

MIMETIC (Monitoring the Immune Modulating Effects in CRAFT)

Program: CI Funding Line: UPGRADE Project type: research project Partner site: Dresden, Frankfurt/Mainz, Heidelberg Entity: multiple entities Status: current

Molecular Diagnostics for Pediatric Cancers

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Berlin, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: cancer in childhood and adolescence, multiple entities Status: completed

MTBA (Molecular Tumor Board Alliance)

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: completed

MultiPro (Development of therapeutic vaccines. Multipeptide-based phase I/II clinical study for biochemically relapsed prostate carcinoma patients independent of HLA typing)

Program: CI Funding Line: INNOVATION Project type: research project Partner site: Dresden, Heidelberg, Munich, Tubingen Entity: prostate cancer Status: completed

NEO-ATT (Targeting recurrent cancer mutations by T cell therapy)

Program: CI Funding Line: INNOVATION Project type: research project Partner site: Berlin, Essen/Dusseldorf, Frankfurt/Mainz, Heidelberg Entity: multiple entities, solid tumors Status: completed

NEOLAP/SUBPAN (Subtyping of locally advanced pancreatic cancer)

Program: MDEB Funding Line: UPGRADE Project type: study-related research project Partner site: Berlin, Essen/Dusseldorf, Heidelberg, Munich Entity: pancreatic cancer Status: completed

Next Gen LOGGIC (Next generation therapies for low-grade glioma in children)

Program: MDEB Funding Line: UPGRADE Project type: study-related research project Partner site: Berlin, Essen/Dusseldorf, Freiburg, Heidelberg Entity: brain tumor, cancer in childhood and adolescence Status: completed

Next Generation Molecular Diagnostics of Malignant Gliomas

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich Entity: brain tumor Status: completed

NonCoMs in Cancer Genomes (Identifying and Understanding Non-coding Mutations in Cancer Genome)

Program: EOM Funding Line: INNOVATION Project type: research project Partner site: Dresden, Essen/Dusseldorf, Heidelberg, Tubingen Entity: brain tumor, skin cancer Status: completed

Novel Tools for Functional Analysis of Oncogenic Pathways

Program: EOM Funding Line: INNOVATION Project type: research project Partner site: Berlin, Dresden, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: completed

NoviCARAZA (AML treatment with non-viral CAR-NK cells plus AZA)

Program: CI Funding Line: INNOVATION Project type: research project Partner site: Berlin, Frankfurt/Mainz, Freiburg, Heidelberg, Tubingen Entity: blood cancer Status: current

Overcoming therapy resistance in pancreatic cancers (Development of combinatorial therapies targeting primary and secondary drug resistance of pancreatic cancer subtypes)

Program: EOM Funding Line: INNOVATION Project type: research project Partner site: Berlin, Essen/Dusseldorf, Frankfurt/Mainz, Heidelberg, Munich Entity: pancreatic cancer Status: completed

PARADIGM (Predicting Abscopal effects after RADiotherapy and Immune-checkpoint inhibition via integrative Genomics in Melanoma)

Program: ROI Funding Line: INNOVATION Project type: IIT/clinical study Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: skin cancer Status: completed

PerVision (Personalized vaccination in fusion + sarcoma patients)

Program: CI Funding Line: INNOVATION Project type: IIT/clinical study Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: multiple entities Status: current

PEVIDS (Personalized Tertiary Cancer Prevention)

Program: MDEB Funding Line: UPGRADE Project type: study-related research project Partner site: Heidelberg, Munich, Tubingen Entity: colon cancer Status: current

PredictAHR (AHR signature technology as a predictor for therapy response in cancer)

Program: MDEB Funding Line: INNOVATION Project type: research project Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Heidelberg, Munich Entity: multiple entities Status: current

PSMAxCD3 (PSMAxCD3 bsAb in CRPC and NSCLC)

Program: CI Funding Line: INNOVATION Project type: IIT/clinical study Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Tubingen Entity: prostate cancer Status: completed

RadOncHNSCC (Radiobiological profiling for biologically stratified radiochemotherapy of HNSCC)

Program: ROI Funding Line: INNOVATION Project type: IIT/clinical study Partner site: Berlin, Dresden, Essen/Dusseldorf, Frankfurt/Mainz, Freiburg, Heidelberg, Munich, Tubingen Entity: head and neck cancer Status: completed

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